Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis.

ABSTRACT: High-mobility group protein 1 (HMGA1) participates in the processes of DNA transcription, replication, recombination, and repair. The HMGA1 gene is expressed abundantly during embryogenesis and is reactivated during carcinogenesis. HMGA1 gene expression has been associated with a high degree of malignancy, metastatic tendency, and poor survival in breast, colon, ovary, and pancreatic cancers. However, its prognostic significance in lung cancer remains unclear. Using publicly available data, HMGA1 was shown to be overexpressed in both small and non-small lung tumors, with higher expression compared to both the adjacent non-malignant lung tissues and non-tumor lung tissues of healthy individuals. Elevated HMGA1 expression could result from lowered HMGA1 met

SUBMITTER: Saed L 

PROVIDER: S-EPMC9266824 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature