Therapeutic Effects of Quetiapine and 5-HT_1A Receptor Agonism on Hyperactivity in Dopamine-Deficient Mice.

ABSTRACT: Some diseases that are associated with dopamine deficiency are accompanied by psychiatric symptoms, including Parkinson's disease. However, the mechanism by which this occurs has not been clarified. Previous studies found that dopamine-deficient (DD) mice exhibited hyperactivity in a novel environment. This hyperactivity is improved by clozapine and donepezil, which are used to treat psychiatric symptoms associated with dopamine deficiency (PSDD). We considered that DD mice could be used to study PSDD. In the present study, we sought to identify the pharmacological mechanism of PSDD. We conducted locomotor activity tests by administering quetiapine and drugs that have specific actions on serotonin (5-hydroxytryptamine [5-HT]) receptors and muscarinic receptors. Changes in neuronal activity

SUBMITTER: Ochiai Y 

PROVIDER: S-EPMC9266854 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature