The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis.

ABSTRACT:

Introduction

The reported relationship between coffee intake and renal function is poorly understood. By applying two-sample Mendelian randomization (MR) and systematic review and meta-analysis we investigated the association of caffeine and coffee intake with prevalent CKD and markers of renal function.

Material and methods

For the individual data analysis we analyzed the National Health and Nutrition Examination Surveys (NHANES) data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever genome-wide association studies (GWAS) conducted on coffee intake (N = 91,462) and kidney function (N = 133,413). The inverse variance weighted method (IVW), weighted median-based method, MR-Egger, MR-RAPS, and MR-P

SUBMITTER: Mazidi M 

PROVIDER: S-EPMC9266873 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature