Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification.

ABSTRACT: The term heterotopic ossification (HO) describes bone formation in tissues where bone is normally not present. Musculoskeletal trauma induces signalling events that in turn trigger cells, probably of mesenchymal origin, to differentiate into bone. The aetiology of HO includes extremely rare but severe, generalised and fatal monogenic forms of the disease; and as a common complex disorder in response to musculoskeletal, neurological or burn trauma. The resulting bone forms through a combination of endochondral and intramembranous ossification, depending on the aetiology, initiating stimulus and affected tissue. Given the heterogeneity of the disease, many cell types and biological pathways have been studied in efforts to find effective therapeutic strategies for the disorder. Cells of mesen

SUBMITTER: Felix-Ilemhenbhio F 

PROVIDER: S-EPMC9266941 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature