Gene Mutational Clusters in the Tumors of Colorectal Cancer Patients With a Family History of Cancer.

ABSTRACT:

Introduction

Family history is a high-risk factor for colorectal cancer (CRC). The risk comes not only from known germline mutations but also from the other family-related mechanisms. Uncovering them would be an important step to improve the diagnosis and treatment of these patients.

Method

Samples from 168 patients with advanced CRC were collected and applied to next-generation sequencing of 624 pan-cancer genes. Genomic mutations and significantly mutated genes were identified. Significantly mutated genes and co-mutated genes were used to cluster patients. For each cluster of patients, mutational signatures were extracted. The identified mutational signatures were further validated in the other independent cohort.

Result

Significantly mutated genes including TP53

SUBMITTER: Huang H 

PROVIDER: S-EPMC9266985 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature