Musculoskeletal tissue engineering: Adipose derived stromal cell implementation for the treatment of osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a progressive degenerative joint disease which results in chronic degeneration of articular cartilage and sclerosis of bone. While tendons and ligaments may heal to a limited extent, articular cartilage has poor intrinsic regenerative potential, and critical-sized bone defects and pathological fractures cannot regenerate spontaneously. OA represents a significant burden of disease globally, affecting 240 million people in the world. The objective of tissue engineering is to recapitulate the natural healing cascade and developmental process by transplanting stromal and progenitor cells which can act directly or indirectly. As the ultimate goal of regenerative medicine is to avoid in vitro expansion of cells and its associated complications, the adipose-derived stromal

SUBMITTER: Tevlin R 

PROVIDER: S-EPMC9267037 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature