Efficacy and Outcomes of CYP3A5 Genotype-Based Tacrolimus Dosing Compared to Conventional Body Weight-based Dosing in Living Donor Kidney Transplant Recipients.

ABSTRACT:

Introduction

Clinical use of tacrolimus has been challenging due to its narrow therapeutic index and highly variable pharmacokinetics. In this study, we compared patients who received body weight-based tacrolimus dosing pre-transplant (transplanted from 2016 to 2018) with those who received CYP3A5 genotype-based dosing (2018 to 2020).

Methods

Eighty-two renal transplant recipients were non-randomly assigned to genotype-adapted or bodyweight-based tacrolimus dosing groups. The primary end point was to study the proportion of subjects who achieved the target tacrolimus C₀ on post-op day 4. Secondary end points included clinical outcomes and safety.

Results

The proportion of subjects who achieved the target tacrolimus C₀ on postoperative days 4 and

SUBMITTER: Raj TY 

PROVIDER: S-EPMC9267083 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature