Biocompatibility of ZrO₂ vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography.

ABSTRACT: The osseointegration of implants is defined as the direct anatomical and functional connection between neoformed living bone and the surface of a supporting implant. The biological compatibility of implants depends on various parameters, such as the nature of the material, chemical composition, surface topography, chemistry and loading, surface treatment, and physical and mechanical properties. In this context, the objective of this study is to evaluate the biocompatibility of rough (Ra = 1 µm) and smooth (Ra = 0 µm) surface conditions of yttria-zirconia (Y-TZP) discs compared to pure zirconia (ZrO₂) discs by combining a classical toxicological test, morphological observations by SEM, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. Similar cell pro

SUBMITTER: Tchinda A 

PROVIDER: S-EPMC9267226 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature