Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers.

ABSTRACT: Graft copolymers based on a choline ionic liquid (IL), [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), were obtained by atom transfer radical polymerization. The presence of chloride counterions in the trimethylammonium groups promoted anion exchange to introduce fusidate anions (FUS, 32-55 mol.%) as the pharmaceutical anions. Both the choline-based IL copolymers and their ionic drug-carrier conjugates (FUS systems as the first type, 26-208 nm) formed micellar structures (CMC = 0.011-0.025 mg/mL). The amphiphilic systems were advantageous for the encapsulation of rifampicin (RIF, 40-67 mol.%), a well-known antibiotic, resulting in single-drug (RIF systems as the second type, 40-95 nm) and dual-drug systems (FUS/RIF as the third type, 31-65 nm). The obtained systems released

SUBMITTER: Niesyto K 

PROVIDER: S-EPMC9267481 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature