Ferritin Trajectories over Repeated Whole Blood Donations: Results from the FIND+ Study.

ABSTRACT:

Background

Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations.

Methods

Ferritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over two years in an observational cohort study. Latent classes of ferritin level trajectories were investigated separately using growth mixture models for male and female donors. General linear mixed models assessed associations of ferritin levels with subsequent iron deficiency and/or low hemoglobin.

Results

Two groups of donors were identified using group-based trajectory modeling

SUBMITTER: Moazzen S 

PROVIDER: S-EPMC9267857 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature