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Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora.

ABSTRACT: Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1-3 showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds 1-2 exhibited more potent inhibitory activity than compound 3. The cytotoxicity of compounds 1-3 against human hepatocellular carcinoma HepG2 cells and human gastric carcinoma SGC-7901 cells were evaluated, while all of them exhibited no cytotoxicity.

SUBMITTER: Guo X

PROVIDER: S-EPMC9267982 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Two New Seco-Labdane Diterpenoids from the Leaves of Callicarpa nudiflora.

Guo Xia X Zhang Yao Y Xiao Yin Y Zhou Lu L Yin Shaoyang S Sheng Xifeng X Xiang Hongling H Zou Hui H

Molecules (Basel, Switzerland) 20220622 13

Two new seco-labdane diterpenoids, nudiflopene N (1) and nudiflopene O (2), and four known compounds were isolated from the leaves of Callicarpa nudiflora. The structures of the new compounds were established by 1D-, 2D-NMR, and HR-ESI-MS spectral analyses. Compounds 1-3 showed inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells, and new compounds 1-2 exhibited more potent inhibitory activity than compound 3 ...[more]

PMID: 35807261

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