Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPARγ.

ABSTRACT: Diabetes associated with post-menopause is related to a worse condition of kidney disease. Taking into consideration that this disorder may be regulated by estrogenic mediators, we evaluated the renal protective effect of isoflavone. We investigated the role of the PPARγ in the pathogenesis of the disease. For this study, we used diabetic female rats in a postmenopausal model through ovariectomy. The animals were treated with isoflavone or 17β-estradiol. A dosage was administered to bring on blood glycemia, and through immunohistochemistry, we evaluated the immunoreactivity of PPARγ in the endometrium and renal tissue. We analyzed the immunoreactivity of renal injury molecule KIM-1 and the collagen and glycogen densities in the kidney. Through bioinformatics analysis, we observed PPARγ<

SUBMITTER: Ferraz Carbonel AA 

PROVIDER: S-EPMC9268059 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature