Ontology highlight
ABSTRACT:
SUBMITTER: Orlandin A
PROVIDER: S-EPMC9268172 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20220630 13
The suppression of side reactions is one of the most important objectives in peptide synthesis, where highly reactive compounds are involved. Recently, the violuric acid derivative Oxyma-B was introduced into peptide synthesis protocols as a promising additive to efficiently control the optical purity of the amino acids prone to racemization. However, we discovered a side reaction involving the Beckmann rearrangement of Oxyma-B during the coupling reaction, which compromises the yield and purity ...[more]