Safranal Induces Vasorelaxation by Inhibiting Ca²⁺ Influx and Na⁺/Ca²⁺ Exchanger in Isolated Rat Aortic Rings.

ABSTRACT: Introduction: Safranal, which endows saffron its unique aroma, causes vasodilatation and has a hypotensive effect in animal studies, but the mechanisms of these effects are unknown. In this study, we investigated the mechanisms of safranal vasodilation. Methods: Isolated rat endothelium-intact or -denuded aortic rings were precontracted with phenylephrine and then relaxed with safranal. To further assess the involvement of nitric oxide, prostaglandins, guanylate cyclase, and phospholipase A₂ in safranal-induced vasodilation, aortic rings were preincubated with L-NAME, indomethacin, methylene blue, or quinacrine, respectively, then precontracted with phenylephrine, and safranal concentration-response curves were established. To explore the effects of safranal on Ca<

SUBMITTER: Al-Saigh NN 

PROVIDER: S-EPMC9268204 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature