Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines.

ABSTRACT: In vitro studies can help reveal the biochemical pathways underlying the origin of volatile indicators of numerous diseases. The key objective of this study is to identify the potential biomarkers of gastric cancer. For this purpose, the volatilomic signatures of two human gastric cancer cell lines, AGS (human gastric adenocarcinoma) and SNU-1 (human gastric carcinoma), and one normal gastric mucosa cell line (GES-1) were investigated. More specifically, gas chromatography mass spectrometry has been applied to pinpoint changes in cell metabolism triggered by cancer. In total, ten volatiles were found to be metabolized, and thirty-five were produced by cells under study. The volatiles consumed were mainly six aldehydes and two heterocyclics, whereas the volatiles released embraced twelve ke

SUBMITTER: Slefarska-Wolak D 

PROVIDER: S-EPMC9268292 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature