Antiproliferative and Antimicrobial Effects of Rosmarinus officinalis L. Loaded Liposomes.

ABSTRACT: Rosmarinus officinalis L. is a species that is widely known for its culinary and medicinal uses. The purpose of the present study consisted of the evaluation of the antiproliferative and antimicrobial effects of R. officinalis-loaded liposomes (L-R). Characterization of the liposomes was performed by establishing specific parameters. The load of the obtained liposomes was analyzed using an LC-MS method, and antiproliferative assays evaluated the cell viability on a liver adenocarcinoma cell line and on a human hepatic stellate cell line. Antimicrobial assays were performed by agar-well diffusion and by broth microdilution assays. The obtained liposomes showed high encapsulation efficiency, suitable particle size, and good stability. High amounts of caffeic (81.07 ± 0.76), chl

SUBMITTER: Ielciu I 

PROVIDER: S-EPMC9268459 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature