Potent Activity of a High Concentration of Chemical Ozone against Antibiotic-Resistant Bacteria.

ABSTRACT:

Background

Health care-associated infections (HAIs) are a significant public health problem worldwide, favoring multidrug-resistant (MDR) microorganisms. The SARS-CoV-2 infection was negatively associated with the increase in antimicrobial resistance, and the ESKAPE group had the most significant impact on HAIs. The study evaluated the bactericidal effect of a high concentration of O₃ gas on some reference and ESKAPE bacteria.

Material and methods

Four standard strains and four clinical or environmental MDR strains were exposed to elevated ozone doses at different concentrations and times. Bacterial inactivation (growth and cultivability) was investigated using colony counts and resazurin as metabolic indicators. Scanning electron microscopy (SEM) was performed.

SUBMITTER: Rangel K 

PROVIDER: S-EPMC9268618 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature