Multimodal in vivo staging in amyotrophic lateral sclerosis using artificial intelligence.

ABSTRACT:

Background

The underlying neuropathological process of amyotrophic lateral sclerosis (ALS) can be classified in a four-stage sequential pTDP-43 cerebral propagation scheme. Using diffusion tensor imaging (DTI), in vivo imaging of these stages has already been shown to be feasible for the specific corticoefferent tract systems. Because both cognitive and oculomotor dysfunctions are associated with microstructural changes at the brain level in ALS, a cognitive and an oculomotor staging classification were developed, respectively. The association of these different in vivo staging schemes has not been attempted to date.

Methods

A total of 245 patients with ALS underwent DTI, video-oculography, and cognitive testing using Edinburgh Cognitive and Behavioral ALS Screen (ECAS). A s

SUBMITTER: Behler A 

PROVIDER: S-EPMC9268886 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature