Inertia-Acoustophoresis Hybrid Microfluidic Device for Rapid and Efficient Cell Separation.

ABSTRACT: In this paper, we proposed an integrated microfluidic device that could demonstrate the non-contact, label-free separation of particles and cells through the combination of inertial microfluidics and acoustophoresis. The proposed device integrated two microfluidic chips which were a PDMS channel chip on top of the silicon-based acoustofluidic chip. The PDMS chip worked by prefocusing the particles/cells through inducing the inertial force of the channel structure. The connected acoustofluidic chips separated particles based on their size through an acoustic radiation force. In the serpentine-shaped PDMS chip, particles formed two lines focusing in the channel, and a trifugal-shaped acoustofluidic chip displaced and separated particles, in which larger particles focused on the central chann

SUBMITTER: Kim U 

PROVIDER: S-EPMC9268962 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature