Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.

ABSTRACT: Understanding the causes and consequences of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet difficult to achieve because they arise in the context of variable human behavior and immunity. We investigated the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus genomes, and community-based polymerase chain reaction data. We identified a multistage spatial invasion process in which early B.1.1.7 growth rates were associated with mobility and asymmetric lineage export from a dominant source location, enhancing the effects of B.1.1.7's increased intrinsic transmissibility. We further explored how B.1.1.7 spread was shaped by nonpharmaceutical interventions and spatial var

SUBMITTER: Kraemer MUG 

PROVIDER: S-EPMC9269003 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature