Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD⁺ by Generating Dihydronicotinamide Riboside.

ABSTRACT: Through evolution, eukaryote organisms have developed the ability to use different molecules as independent precursors to generate nicotinamide adenine dinucleotide (NAD⁺), an essential molecule for life. However, whether these different precursors act in an additive or complementary manner is not truly well understood. Here, we have evaluated how combinations of different NAD⁺ precursors influence intracellular NAD⁺ levels. We identified dihydronicotinic acid riboside (NARH) as a new NAD⁺ precursor in hepatic cells. Second, we demonstrate how NARH, but not any other NAD⁺ precursor, can act synergistically with nicotinamide riboside (NR) to increase NAD⁺ levels in cultured cells and in mice. Finally, we demonstrate that the

SUBMITTER: Ciarlo E 

PROVIDER: S-EPMC9269339 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature