Association between MTR A2756G polymorphism and susceptibility to congenital heart disease: A meta-analysis.

ABSTRACT: The association between methionine synthase (MTR) A2756G (rs1805087) polymorphism and the susceptibility to congenital heart disease (CHD) has not been fully determined. A meta-analysis of case-control studies was performed to systematically evaluate the above association. Studies were identified by searching the PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases from inception to June 20, 2021. Two authors independently performed literature search, data extraction, and quality assessment. Predefined subgroup analyses were carried out to evaluate the impact of the population ethnicity, source of healthy controls (community or hospital-based), and methods used for genotyping on the outcomes. A random-effects model was used to combine the results,

SUBMITTER: Liu W 

PROVIDER: S-EPMC9269412 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature