APOL1 Kidney Risk Variants and Proteomics.

ABSTRACT:

Background and objectives

The APOL1 risk variants (G1 and G2) are associated with kidney disease among Black adults, but the clinical presentation is heterogeneous. In mouse models and cell systems, increased gene expression of G1 and G2 confers cytotoxicity. How APOL1 risk variants relate to the circulating proteome warrants further investigation.

Design, setting, participants, & measurements

Among 461 African American Study of Kidney Disease and Hypertension (AASK) participants (mean age: 54 years; 41% women; mean GFR: 46 ml/min per 1.73 m²), we evaluated associations of APOL1 risk variants with 6790 serum proteins (measured via SOMAscan) using linear regression models. Covariates included age, sex, percentage of European ancestry, an

SUBMITTER: Chen TK 

PROVIDER: S-EPMC9269576 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature