Apolipoprotein L1 High-Risk Genotypes and Albuminuria in Sub-Saharan African Populations.

ABSTRACT:

Background and objectives

Recessive inheritance of African-specific APOL1 kidney risk variants is associated with higher risk of nondiabetic kidney disease, progression to kidney failure, and early-onset albuminuria that precedes eGFR decline. The effect of APOL1 risk variants on kidney disease in continental Africans is understudied. Objectives of this study were to determine APOL1 risk allele prevalence and associations between APOL1 genotypes and kidney disease in West, East, and South Africa.

Design, setting, participants, & measurements

This cross-sectional population-based study in four African countries included 10,769 participants largely aged 40-60 years with sociodemographic and health information, anthropometry data, and blood and urine

SUBMITTER: Brandenburg JT 

PROVIDER: S-EPMC9269651 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature