The association between Alu hypomethylation and the severity of hypertension.

ABSTRACT:

Introduction

Epigenetic changes that cause genomic instability may be the basis of pathogenic processes of age-associated noncommunicable diseases (NCDs). Essential hypertension is one of the most common NCDs. Alu hypomethylation is an epigenetic event that is commonly found in elderly individuals. Epigenomic alterations are also found in age-associated NCDs such as osteoporosis and diabetes mellitus. Alu methylation prevents DNA from being damaged. Therefore, Alu hypomethylated DNA accumulates DNA damage and, as a result, causes organ function deterioration. Here, we report that Alu hypomethylation is a biomarker for essential hypertension.

Results

We investigated Alu methylation levels in white blood cells from normal controls, patients with prehypertension, and patients w

SUBMITTER: Thongsroy J 

PROVIDER: S-EPMC9269909 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature