The topology of genome-scale metabolic reconstructions unravels independent modules and high network flexibility.

ABSTRACT: The topology of metabolic networks is recognisably modular with modules weakly connected apart from sharing a pool of currency metabolites. Here, we defined modules as sets of reversible reactions isolated from the rest of metabolism by irreversible reactions except for the exchange of currency metabolites. Our approach identifies topologically independent modules under specific conditions associated with different metabolic functions. As case studies, the E.coli iJO1366 and Human Recon 2.2 genome-scale metabolic models were split in 103 and 321 modules respectively, displaying significant correlation patterns in expression data. Finally, we addressed a fundamental question about the metabolic flexibility conferred by reversible reactions: "Of all Directed Topologies (DTs) defined by fixin

SUBMITTER: Martinez VS 

PROVIDER: S-EPMC9269948 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature