Increased non-typhoidal Salmonella hospitalizations in transfusion-naive thalassemia children: a nationwide population-based cohort study.

ABSTRACT:

Introduction

Although non-typhoidal Salmonella (NTS) infection usually causes self-limited enterocolitis, several risk factors have been found to predispose individuals to more severe NTS infections. However, few studies have discussed the association between NTS infection and pediatric thalassemia populations.

Material and methods

A nationwide population-based retrospective cohort study was conducted using medical records of the selected children from the Taiwan National Health Insurance Research Database. Immunocompromised individuals or patients with a history of transfusion or splenectomy were excluded. One thalassemia patient was matched with four non-thalassemia patients based on their year of birth, sex, and urbanization level.

Results

In this cohort, 912 patie

SUBMITTER: Sheen JM 

PROVIDER: S-EPMC9270223 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature