Spontaneous preterm delivery is reflected in both early neonatal and maternal gut microbiota.

ABSTRACT:

Background

Aberrant gut microbiota composition in preterm neonates is linked to adverse health consequences. Little is known about the impact of perinatal factors or maternal gut microbiota on initial preterm gut colonization.

Methods

Fecal samples were collected from 55 preterm neonates (<35 gestational weeks), 51 mothers, and 25 full-term neonates during the first 3-4 postpartum days. Gut microbiota composition was assessed using 16S ribosomal RNA gene sequencing.

Results

Preterm neonates exhibited significantly lower gut microbiota alpha diversity and distinct beta diversity clustering compared to term neonates. Spontaneous preterm birth was associated with distinct initial gut microbiota beta diversity as compared to iatrogenic delivery. Gestational age or deliver

SUBMITTER: Hiltunen H 

PROVIDER: S-EPMC9270225 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature