A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.

ABSTRACT:

Background

Diabetes in childhood and adolescence includes autoimmune and non-autoimmune forms with heterogeneity in clinical and biochemical presentations. An unresolved question is whether there are subtypes, endotypes, or theratypes within these forms of diabetes.

Methods

The multivariable classification and regression tree (CART) analysis method was used to identify subgroups of diabetes with differing residual C-peptide levels in patients with newly diagnosed diabetes before 20 years of age (n=1192). The robustness of the model was assessed in a confirmation and prognosis cohort (n=2722).

Findings

The analysis selected age, haemoglobin A1c (HbA1c), and body mass index (BMI) as split parameters that classified patients into seven islet autoantibody-positive and thr

SUBMITTER: Achenbach P 

PROVIDER: S-EPMC9270253 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature