Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.

ABSTRACT: Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics - arising from a saddle-node homoclinic orbit bifurcation - that so far has received little attention. We show that this type of dynamics is to be expected by specific changes in common physiological parameters, like an elevation of temperature. Moreover, we demonstrate that it favours synchronization patterns in networks - a feature that becomes particularly prominent when system parameters change such that homoclinic spiking is induced. Supported by in-vitro hallmarks for homoclinic spikes in the rodent brain, we hypothesize that the pr

SUBMITTER: Hesse J 

PROVIDER: S-EPMC9270341 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature