Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca²⁺ Handling and NRF2 Activation.

ABSTRACT: Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca²⁺ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.

SUBMITTER: Val-Blasco A 

PROVIDER: S-EPMC9270570 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature