Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline.

ABSTRACT:

Introduction

Evidence from epidemiology, neuroimaging, and animal models indicates that asthma adversely affects the brain, but the nature and extent of neuropathophysiological impact remain unclear.

Methods

We tested the hypothesis that asthma is a risk factor for dementia by comparing cognitive performance and cerebrospinal fluid biomarkers of glial activation/neuroinflammation, neurodegeneration, and Alzheimer's disease (AD) pathology in 60 participants with asthma to 315 non-asthma age-matched control participants (45-93 years), in a sample enriched for AD risk.

Results

Participants with severe asthma had higher neurogranin concentrations compared to controls and those with mild asthma. Positive relationships between cardiovascular risk and concentrations of neuro

SUBMITTER: Nair AK 

PROVIDER: S-EPMC9270636 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature