Monomeric C-reactive protein induces the cellular pathology of Alzheimer's disease.

ABSTRACT:

Introduction

Human study shows that elevated C-reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD). However, whether CRP is directly involved in cellular AD pathogenesis and in which type of neuronal cells of APOE ε4 carriers are unknown.

Methods

We aimed to use different primary neuronal cells and investigate if CRP induces cellular AD pathology depending on APOE genotypes. Here the different primary neuronal cells from the different APOE genotype knock-in mice cortex were isolated and used.

Results

Monomeric CRP (mCRP) increased amyloid beta production and, in parallel, induced tau phosphorylation in addition to their relate

SUBMITTER: Gan Q 

PROVIDER: S-EPMC9270638 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature