Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease.

ABSTRACT:

Introduction

This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD).

Methods

A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO₂peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories.

Results

Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P < .01) and visual learning and memory (P < .042). Secondary analyses indicated that these effects

SUBMITTER: Vesperman CJ 

PROVIDER: S-EPMC9270660 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature