Innate immune regulation in HIV latency models.

ABSTRACT:

Background

Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the HIV reservoir in vivo. Latently infected cells persist through antiretroviral therapy (ART) and are a major barrier to HIV cure. Here, we evaluated innate immunity and IFN responses in multiple T cell models of HIV latency, including established latent cell lines, Jurkat cells latently infected with a reporter virus, and a primary CD4 + T cell model of virologic suppression.

Results

We found that while latently infected T cell lines have functional RNA sensing and IFN signaling pathways, they fail to induce specific interfer

SUBMITTER: Olson RM 

PROVIDER: S-EPMC9270781 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature