Plasmodium berghei Brca2 is required for normal development and differentiation in mice and mosquitoes.

ABSTRACT:

Background

Malaria is a major global parasitic disease caused by species of the genus Plasmodium. Zygotes of Plasmodium spp. undergo meiosis and develop into tetraploid ookinetes, which differentiate into oocysts that undergo sporogony. Homologous recombination (HR) occurs during meiosis and introduces genetic variation. However, the mechanisms of HR in Plasmodium are unclear. In humans, the recombinases DNA repair protein Rad51 homolog 1 (Rad51) and DNA meiotic recombinase 1 (Dmc1) are required for HR and are regulated by breast cancer susceptibility protein 2 (BRCA2). Most eukaryotes harbor BRCA2 homologs. Nevertheless, these have not been reported for Plasmodium.

Methods

A Brca2 candidate was salvaged from a database to identify Brca2 homologs in Plasmodium. To confirm th

SUBMITTER: Yoshikawa Y 

PROVIDER: S-EPMC9270840 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature