MMP2 Polymorphisms and Colorectal Cancer Susceptibility in a Chinese Han Population.

ABSTRACT:

Purpose

Colorectal cancer (CRC) is among the most common cancers worldwide and an important cause of cancer-related death. Inherited genetic variation plays a vital role in the occurrence and development of CRC. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in MMP2 with CRC risk.

Patients and methods

Three candidates, MMP2 SNPs, rs1053605, rs243849, and rs14070, were selected and genotyped using the Agena MassARRAY RS1000 system, and their association with risk of CRC was evaluated in 663 CRC cases and 663 healthy controls by calculating odds ratio (OR) with 95% confidence interval (95% CI) values.

Results

The minor allele of rs243849 (T) was significantly less frequent in cases than controls (p =

SUBMITTER: Liu X 

PROVIDER: S-EPMC9270925 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature