Chick cranial neural crest cells release extracellular vesicles that are critical for their migration.

ABSTRACT: The content and activity of extracellular vesicles purified from cell culture media or bodily fluids have been studied extensively; however, the physiological relevance of exosomes within normal biological systems is poorly characterized, particularly during development. Although exosomes released by invasive metastatic cells alter migration of neighboring cells in culture, it is unclear whether cancer cells misappropriate exosomes released by healthy differentiated cells or reactivate dormant developmental programs that include exosome cell-cell communication. Using chick cranial neural fold cultures, we show that migratory neural crest cells, a developmentally critical cell type and model for metastasis, release and deposit CD63-positive 30-100 nm particles into the extracellular environ

SUBMITTER: Gustafson CM 

PROVIDER: S-EPMC9270958 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature