Gastric and gastroesophageal junction cancer: Risk factors and prophylactic treatments for prevention of peritoneal recurrence after curative intent surgery.

ABSTRACT:

Aim

Relapse after curative treatment for advanced gastric cancer, and especially peritoneal recurrence, is very common and has a dismal prognosis. The aim of this review is to summarize existing evidence regarding risk factors and prophylactic treatments intending to prevent peritoneal recurrence.

Methods

A structured search of relevant studies was conducted in MEDLINE, Embase, and the Cochrane Library.

Results

The main risk factors identified are advanced pathological T-stage (pT ≥ 3), regional lymph node involvement, diffuse/poorly cohesive type tumor, poorly differentiated cancer, and positive peritoneal wash cytology. Systemic chemotherapy in the perioperative or adjuvant setting improves survival for the patients but despite this peritoneal recurrence remains a c

SUBMITTER: Huang B 

PROVIDER: S-EPMC9271029 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature