Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.

ABSTRACT:

Objective

Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.

Design

We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine the biological significance of the most frequent communication route, we used pancreatic ductal adenocarcinoma (PDAC) orthotopic models, patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMMs).

Results

We demonstrate that PDAC tumours establish an organised communication network between subpopulations of cancer cells using EVs called the EV

SUBMITTER: Ruivo CF 

PROVIDER: S-EPMC9271144 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature