Adolescent development of multiscale structural wiring and functional interactions in the human connectome.

ABSTRACT: Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y (n = 199). Core to our work was an advanced in vivo model of cortical wiring incorporating MRI features of corticocortical proximity, microstructural similarity, and white matter tractography. Longitudinal analyses assessing age-related changes in cortical wiring identified a continued differentiation of multiple corticocortical structural networks in youth. We then assessed structure-function coupling using resting-state functional MRI measures in the same participants both via cross-sectional analysis at baseline and by studying longitudinal change between baseline

SUBMITTER: Park BY 

PROVIDER: S-EPMC9271154 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature