Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.

ABSTRACT: Correlated activity of neurons can lead to long-term strengthening or weakening of the connections between them. In addition, the behavioral context, imparted by execution of physical movements or the presence of a reward, can modulate the plasticity induced by Hebbian mechanisms. In the present study, we have combined behavior and induced neuronal correlations to strengthen connections in the motor cortex of adult behaving monkeys. Correlated activity was induced using an electrical-conditioning protocol in which stimuli gated by voluntary movements were used to produce coactivation of neurons at motor-cortical sites involved in those movements. Delivery of movement-dependent stimulation resulted in small increases in the strength of associated cortical connections immediately after condi

SUBMITTER: Moorjani S 

PROVIDER: S-EPMC9271159 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature