C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

ABSTRACT: All cells contain specialized signaling pathways that enable adaptation to specific molecular stressors. Yet, whether these pathways are centrally regulated in complex physiological stress states remains unclear. Using genome-scale fitness screening data, we quantified the stress phenotype of 739 cancer cell lines, each representing a unique combination of intrinsic tumor stresses. Integrating dependency and stress perturbation transcriptomic data, we illuminated a network of genes with vital functions spanning diverse stress contexts. Analyses for central regulators of this network nominated C16orf72/HAPSTR1, an evolutionarily ancient gene critical for the fitness of cells reliant on multiple stress response pathways. We found that HAPSTR1 plays a pleiotropic role in cellular stress signa

SUBMITTER: Amici DR 

PROVIDER: S-EPMC9271168 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature