Nanoparticle-blockage-enabled rapid and reversible nanopore gating with tunable memory.

ABSTRACT: Gated protein channels act as rapid, reversible, and fully-closeable nanoscale valves to gate chemical transport across the cell membrane. Replicating or outperforming such a high-performance gating and valving function in artificial solid-state nanopores is considered an important yet unsolved challenge. Here we report a bioinspired rapid and reversible nanopore gating strategy based on controlled nanoparticle blockage. By using rigid or soft nanoparticles, we respectively achieve a trapping blockage gating mode with volatile memory where gating is realized by electrokinetically trapped nanoparticles near the pore and contact blockage gating modes with nonvolatile memory where gating is realized by a nanoparticle physically blocking the pore. This gating strategy can respond to an externa

SUBMITTER: Yazbeck R 

PROVIDER: S-EPMC9271175 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature