Distinct gene expression dynamics in developing and regenerating crustacean limbs.

ABSTRACT: Regenerating animals have the ability to reproduce body parts that were originally made in the embryo and subsequently lost due to injury. Understanding whether regeneration mirrors development is an open question in most regenerative species. Here, we take a transcriptomics approach to examine whether leg regeneration shows similar temporal patterns of gene expression as leg development in the embryo, in the crustacean Parhyale hawaiensis. We find that leg development in the embryo shows stereotypic temporal patterns of gene expression. In contrast, the dynamics of gene expression during leg regeneration show a higher degree of variation related to the physiology of individual animals. A major driver of this variation is the molting cycle. We dissect the transcriptional signals of

SUBMITTER: Sinigaglia C 

PROVIDER: S-EPMC9271199 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature