Relationship of circulating immune cells with lifestyle factors and cancer recurrence in early-stage breast cancer.

ABSTRACT:

Purpose

To evaluate the relationship of circulating immune cells with recurrence and metabolic/lifestyle factors in patients with early-stage breast cancer.

Methods

Patients with early-stage breast cancer were identified from the electronic record and institutional registry. Lymphocyte and monocyte counts were obtained from blood samples at time of diagnosis prior to any chemotherapy. Correlations between lymphocyte and monocyte and recurrence were assessed in the entire cohort and among obese patients, those reporting alcohol consumption and smoking. Competing risk regression was used to analyze time to recurrence.

Results

A total of 950 patients with ≥ 5 years of follow-up were identified; 433 had complete data and were eligible for analysis. 293 (68%) had hormone r

SUBMITTER: Xie E 

PROVIDER: S-EPMC9271265 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature