Multi-omics analysis reveals the panoramic picture of necroptosis-related regulators in pan-cancer.

ABSTRACT:

Background

Unlike apoptosis, necroptosis is a tightly regulated form of programmed cell death (PCD) that occurs in a caspase-independent manner and is mainly triggered by receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 and the RIPK3 substrate mixed-lineage kinase domain-like protein (MLKL). A growing body of evidence has documented that necroptosis, as a novel therapeutic strategy to overcome apoptosis resistance, has potential pro- or anti-tumoral effects in tumorigenesis, metastasis, and immunosurveillance. However, comprehensive multi-omics studies on regulators of necroptosis from a pan-cancer perspective are lacking.

Methods

In the present study, a pan-cancer multi-omics analysis of necroptosis-related regulators was performed by integrating over 1

SUBMITTER: Li G 

PROVIDER: S-EPMC9271292 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature