Mechanical performance of collagen gels is dependent on purity, α1/α2 ratio, and telopeptides.

ABSTRACT: This article describes the compositional, mechanical, and structural differences between collagen gels fabricated from different sources and processing methods. Despite extensive use of collagen in the manufacturing of biomaterials and implants, there is little information as to the variation in properties based on collagen source or processing methods. As such, differences in purity and composition may affect gel structure and mechanical performance. Using mass spectrometry, we assessed protein composition of collagen from seven different sources. The mechanics and gelation kinetics of each gel were assessed through oscillatory shear rheology. Scanning electron microscopy enabled visualization of distinct differences in fiber morphology. Mechanics and gelation kinetics differed with sourc

SUBMITTER: Slyker L 

PROVIDER: S-EPMC9271356 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature