CtDNA as a biomarker of progression in oesophageal adenocarcinoma.

ABSTRACT:

Background

The incidence of oesophageal adenocarcinoma (OAC) is rapidly increasing and despite improvements in treatment, the 5-year survival rate remains poor. Prognostic biomarkers that address the genomic heterogeneity in this highly complex disease will aid the development of precision therapeutics and improve patient survival. The aim of this study was to determine whether circulating tumour DNA (ctDNA) has prognostic significance as a biomarker in OAC patients.

Patients and methods

We profiled 209 blood and tumour samples from 57 OAC patients. Using a panel of 77 cancer genes, we sequenced ctDNA in plasma samples (n = 127) which were taken at multiple time points before and after therapy. In parallel, we sequenced matched tumour samples from 39 patients using the same

SUBMITTER: Bonazzi VF 

PROVIDER: S-EPMC9271467 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature