Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection.

ABSTRACT: Recent studies have shown that methylation changes identified in blood cells of COVID-19 patients have a potential to be used as biomarkers of SARS-CoV-2 infection outcomes. However, different studies have reported different subsets of epigenetic lesions that stratify patients according to the severity of infection symptoms, and more importantly, the significance of those epigenetic changes in the pathology of the infection is still not clear. We used methylomics and transcriptomics data from the largest so far cohort of COVID-19 patients from four geographically distant populations, to identify casual interactions of blood cells' methylome in pathology of the COVID-19 disease. We identified a subset of methylation changes that is uniformly present in all COVID-19 patients regardless of sy

SUBMITTER: Binkowski J 

PROVIDER: S-EPMC9271528 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature